S2. Peptide Hormones, Growth Factors, Related Substances and mimetics

If a Substance or Method is not defined in this list, please verify with your Anti-Doping Organization.

The following substances, and other substances with similar chemical structure or similar biological effect(s), are prohibited:

1. Erythropoietin-Receptor agonists:

1.1 Erythropoiesis-Stimulating Agents (ESAs) including e.g.

  • darbepoietin (dEPO)
  • erythropoietins (EPO)
  • EPO-Fc
  • EPO-mimetic peptides (EMP) e.g.
    • CNTO 530
    • peginesatide
  • methoxy polyethylene glycol-epoetin beta (CERA).

1.2 Non-erythropoietic EPO-Receptor agonists, e.g.

  • ARA-290
  • asialo EPO
  • carbamylated EPO.

2. Hypoxia-inducible factor (HIF)

  • HIF stabilizers e.g.
    • cobalt
    • FG-4592
  • HIF activators e.g.
    • argon
    • xenon

3. Chorionic Gonadotrophin (CG) and Luteinizing Hormone (LH) and their releasing factors in males, e.g.

  • buserelin
  • gonadorelin
  • leuprorelin

4. Corticotrophins and their releasing factors, e.g.

  • corticorelin

5. Growth Hormone (GH) and its releasing factors including:

  • Growth Hormone Releasing Hormone (GHRH) and its analogues e.g.
    • CJC-1295
    • sermorelin
    • tesamorelin
  • Growth Hormone Secretagogues (GHS) e.g.
    • ghrelin
    • ghrelin mimetics e.g.
      • anamorelin
      • ipamorelin
  • GH-Releasing Peptides (GHRPs) e.g.
    • alexamorelin
    • GHRP-6
    • hexarelin
    • pralmorelin (GHRP-2).

Additional prohibited growth factors:

  • Fibroblast Growth Factors (FGFs);
  • Hepatocyte Growth Factor (HGF);
  • Insulin-like Growth Factor-1 (IGF-1) and its analogues;
  • Mechano Growth Factors (MGFs);
  • Platelet-Derived Growth Factor (PDGF);
  • Vascular-Endothelial Growth Factor (VEGF) and any other growth factor affecting muscle, tendon or ligament protein synthesis/degradation, vascularisation, energy utilization, regenerative capacity or fibre type switching.

If a Substance or Method is not found, please verify with your Anti-Doping Organization to ensure that this Substance or Method is not prohibited as a related Substance or Method that falls under an existing category.